transforming pediatric health care

Gastroenterology

Technically variant grafts significantly close the gap in pediatric liver transplant access

Pediatric split liver transplant surgery is rare, with only 10 U.S. centers offering it. Children’s Health began using technically variant grafts in 2024 and has since doubled the national average, expanding access and reducing waitlist mortality.

Behavioral Health

The Behavioral Health Vehicles Program at Children’s Health provides emergency transport services to children with mental health needs.

The Behavioral Health Vehicles Program at Children’s Health provides emergency transport services to children with mental health needs.

Neurology

In this episode, we discuss the first-in-human gene-based therapy for Lafora disease: A landmark in Pediatric Neurogenetics.

In this episode, we discuss the first-in-human gene-based therapy for Lafora disease: A landmark in Pediatric Neurogenetics.

Nephrology

A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia.

A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia.

Research Article

First multicenter survey reveals wide variation in ECMO candidacy for neonates with severe CAKUT

For neonates with severe CAKUT, ECMO can be lifesaving. But which patients should receive it remains an open question. A Children's Health survey of 42 centers reveals the variation driving that uncertainty and the need for consensus.

Research Article

Rare thyroid case underscores value of multidisciplinary care Inside the lessons learned

Congenital hyperthyroidism is often linked to maternal Graves' disease, but other causes can complicate diagnosis. Specialists at Children’s Health identified a rare “hot” nodule, highlighting the value of early imaging and multidisciplinary care.

Research Article

Long-term study shows positive outcomes for minimally invasive craniosynostosis surgery

Sagittal craniosynostosis leads to a long, narrow head shape with bulging in the front and back. Experts at Children’s Health led the first study to compare long-term outcomes of three minimally invasive surgical techniques.

Research Article

4 evidence-based approaches to improve pediatric non-suicidal self-injury care

About 1 in 5 teens has engaged in non-suicidal self-injury, yet many providers lack training. Explore four evidence-based approaches to improve pediatric NSSI screening, reduce stigma and maintain patient trust.

Research Article

Asthma Management Program reduces pediatric ER visits by 60% through coordinated support

Though controllable, asthma’s burden persists because patients and families need more education and support. Our Asthma Management Program (AMP) helps patients stay ahead of the next crisis by extending care into their daily lives.

Pediatric cochlear implants: Guidance for the early treatment of children with hearing loss

Eligibility for cochlear implants continues to change with devices now available for infants as young as 7 months. A journal paper by a Children’s Health otolaryngologist explores this evolution and provides surgical guidance. Find out more.

Research Article

Adenotonsillectomy may reduce limb movements in children with OSA

Periodic limb movements are common in children with obstructive sleep apnea – and often overlooked. New Children's Health℠ research shows how adenotonsillectomy affects them and what it means for evaluating and treating these patients.

Research Article

First pediatric patient in North Texas receives Lyfgenia for sickle cell disease

Lyfgenia is a “one-time” gene therapy for sickle cell disease, but the process entails multiple stages over many months. The story of our first SCD patient reveals the rigor – and reward – involved in delivering this groundbreaking treatment.

Clinical Trial

A Randomized Controlled Trial of Abdominal Ultrasound (FAST) in Children with Blunt Torso Trauma

This study is a multi-center RCT to determine whether use of the FAST examination impacts care in hemodynamically stable children with blunt torso trauma.

Neurology

Focal Cerebral Arteriopathy Steroid (FOCAS) Trial

This trial in children with suspected focal cerebral arteriopathy (FCA) presenting with arterial ischemic stroke (AIS) or transient ischemic attack (TIA) comparing early corticosteroid treatment versus delayed/no corticosteroid treatment.

Nephrology

A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia.

A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia.

Neurology

Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea

The study is being conducted in order to evaluate objective change in cognition and expressive language after implant and therapy with the Inspire UAS System.

Hematology & Oncology

NCT04690322

Each patient will be randomly assigned to receive either extended half-life factor VIII based replacement therapy or non-FVIII based replacement therapy, which are both standard of care treatment for persons with Hemophilia A.

Cardiology

Protocol Title: A Phase 2/3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants with Heart Failure

This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period.

Pulmonology

NCT05268094

This is a prospective multicenter randomized interventional trial. Participants will be randomized to receive either an SPS or DAS.

Cardiology

NCT06080074

The overall study design is a prospective clinical trial that combines two individual study designs into one common protocol.